Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

Jingkun Zhao,Baochi Ou,Ding-Pei Han,Puxiongzhi Wang,Yaping Zong,Congcong Zhu,Di Liu,Minhua Zheng,Jing Sun,Hao Feng,Aiguo Lu

Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

2017

Jingkun Zhao
Baochi Ou
Ding-Pei Han
Puxiongzhi Wang
Yaping Zong
Congcong Zhu
Di Liu
Minhua Zheng
Jing Sun
Hao Feng
Aiguo Lu

Background Metastasis is a major cause of death in human colorectal cancer patients. However, the contribution of chemokines in the tumor microenvironment to tumor metastasis is not fully understood.

Keywords:

Protein kinase B
Cancer research
Tumor-Derived
Biology
Tumor microenvironment
CXCL5
MAPK/ERK pathway
Colorectal cancer
Oncology
Metastasis
Catenin
Internal medicine
Cell migration
Mesenchyme
Molecular biology
Cancer

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