Genomic DNA functionalized 3D printed materials for drug capture
2018
Since the discovery of nitrogen mustard as an effective anti-cancer agent in the 1940s, and consequently, the concept of
chemotherapy, researchers around the world have been actively developing new and more effective chemotherapeutic agents
to better treat cancer. Traditionally, chemotherapeutic agents work by interfering with cell division. However, by virtue of their
mechanism of action, healthy normal cells can also be targeted and destroyed. As a result, while chemotherapy is an effective
way of managing cancer, the resulting side effects limits its use. One approach currently taken to reduce these side effects is
to deliver the chemotherapy drugs directly to the tumor via transarterial chemoembolization, or other similar procedures.
While this has been effective in reducing systemic toxicity, more can be done to improve this. Ideally, a device that could
sequester any unreacted chemotherapy agents could be installed "downstream" of the tumor prior to them entering systemic
circulation. Such drug-capture materials have yet to be realized. We report the synthesis of genomic DNA
functionalized 3D printed materials that can be used to capture doxorubicin, a commonly used chemotherapy agent. The
efficacy of these materials highlight the possibility of utilizing them in a device that can be deployed in the body for drug
capture.
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