WT1 Haploinsufficiency Supports Milder Renal Manifestation in Two Patients with Denys-Drash Syndrome.

Mara Sanches Guaragna,Juliana Gabriel Ribeiro de Andrade,Bárbara de Freitas Carli,Vera Maria Santoro Belangero,Andréa Trevas Maciel-Guerra,Gil Guerra Júnior,Maricilda Palandi de-Mello

WT1 Haploinsufficiency Supports Milder Renal Manifestation in Two Patients with Denys-Drash Syndrome.

2017

Mara Sanches Guaragna
Juliana Gabriel Ribeiro de Andrade
Bárbara de Freitas Carli
Vera Maria Santoro Belangero
Andréa Trevas Maciel-Guerra
Gil Guerra Júnior
Maricilda Palandi de-Mello

Denys-Drash syndrome (DDS) is characterized by nephropathy, genital abnormalities, and predisposition to Wilms' tumor. DDS patients usually present heterozygous de novo germline WT1

Keywords:

Endocrinology
Genetics
Denys–Drash syndrome
Internal medicine
Germline
Biology
Nephropathy
Cancer research
Haploinsufficiency

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