Establish animal models of bacterial keratitis

Bacterial keratitis is a potentially blinding infectious corneal disease characterized by onset acute and progress fast, and it always lead to severe health complications including visual impairment and ocular penetrating when processing is not seasonable or poorly controlled. Therefore, a reliable animal model which simulates human keratitis is desperately needed and will be of important significance to conduct further study in areas such as the prevention, diagnoses as well as efficacious treatment of human bacterial keratitis. And there are many kinds of modeling approaches at home and abroad, mainly including the early scratching technique and injecting into corneal stroma, the later contact lenses method and excimer laser-in-situ keratomileusis (LASIK) method as well as other models which with a little improvement on these basis, each method has its own apply condition and pro or con. (Int Rev Ophthalmol, 2017, 41: 198-203) Key words: keratitis, bacterial; animal models