The sedimentation coefficients of human jejunal gut hormone storage granules.

Abstract Centrifugation techniques have been applied to human jejunal homogenates to determine the sedimentation coefficients of the peptide hormone storage granules and mitochondria. The manually computed mean values from three experiments were: motilin (3020), gastrin (3300), enteroglucagon (4880), gastric inhibitory poly-peptide (7240), somatostatin (7580). The mean sedimentation coefficient of the mitochondria was 12600. These results provide independent correlates of granule size determined morphologically and provide the basis for determination of changes in disease states affecting the jejunum.