PD-1 Expression in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) and Large B-cell Richter Transformation (DLBCL-RT): A Characteristic Feature of DLBCL-RT and Potential Surrogate Marker for Clonal Relatedness

Rong He,Wei D Ding,David S. Viswanatha,Dong Chen,Min Shi,Daniel L. Van Dyke,Shulan Tian,Linda N. Dao,Sameer A. Parikh,Tait D. Shanafelt,Timothy G. Call,Stephen Maxted Ansell,Jose F. Leis,Ming Mai,Curtis A. Hanson,Karen L. Rech

PD-1 Expression in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) and Large B-cell Richter Transformation (DLBCL-RT): A Characteristic Feature of DLBCL-RT and Potential Surrogate Marker for Clonal Relatedness

2018

Rong He
Wei D Ding
David S. Viswanatha
Dong Chen
Min Shi
Daniel L. Van Dyke
Shulan Tian
Linda N. Dao
Sameer A. Parikh
Tait D. Shanafelt
Timothy G. Call
Stephen Maxted Ansell
Jose F. Leis
Ming Mai
Curtis A. Hanson
Karen L. Rech

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a low-grade B-cell neoplasm and ∼2% to 9% patients develop an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (Richter transformation, DLBCL-RT). Programmed death-1 (PD-1) pathway plays a crucial role in tumor host

Keywords:

Diffuse large B-cell lymphoma
Chronic lymphocytic leukemia
Richter transformation
Lymphocytic lymphoma
Pathology
PD-L1
Surrogate endpoint
B cell
Medicine
Cancer immunotherapy
Somatic evolution in cancer
Aggressive lymphoma
Cancer research
Lymphoma

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