Disturbances in the metabolism of endogenous metals (Zn and Cu) in nickel-exposed rats.

The effect of nickel chloride on tissue concentrations of zinc and copper was studied in female rats. Animals were subjected to repeated exposure to 5 mg Ni/kg. Whole-body retention of zinc increased about 30%, and retention of copper did not change. Increase of the zinc content was observed in liver, but in kidneys, lungs, and brain zinc content decreased. It was also noted that the level of metallothionein was higher in nickel-exposed rat liver than in control rat liver. Concentration of metallothionein was correlated with the metal contents (Ni, Cu, Zn).