Ratlarda metotreksata bağlı oksidatif intestinal hasarda leflunomidinin koruyucu etkisinin araştırılması

Background and Aims: The aim of this study was to investigate the effects of leflunomide treatment in methotrexate-induced oxidative small intestinal injury in rats. Materials and Methods: Forty rats were randomly divided into 4 groups. Methotrexate-induced intestinal injury was induced by single dose intraperitoneal injection of 20 mg/kg methotrexate. After induction, leflunomide (10 mg/kg/day) was administered intragastrically for 5 consecutive days. On the sixth day, homogenized small intestine tissues were examined for superoxide dismutase activity, myeloperoxidase activity, and glutathione and malondialdehyde levels. Results: Leflunomide treatment significantly decreased tissue myeloperoxidase activity and malondialdehyde levels (3.4±0.7, 1.9±0.4, p