Сравнительный анализ адренореактивности эритроцитов у пациентов с инфарктом миокарда в зависимости от выраженности коронарной обструкции

Aim. To study the parameters of beta-adrenergic reactivity of membrane (p-ARM) of erythrocytes in patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) and single-vessel CAD. Material and methods . The study included 40 patients with MI (experimental group — 19 patients; control group — 21 patients). Three patients (15,7%) with diagnosed acute myocarditis were excluded from the analysis. Levels of β -ARM were determined upon admission, on the 2 nd , 4 th and 7 th day after MI. The normal range of β -ARM were 0,05). The curves of β -ARM median changes show its multidirectional dynamics in the studied groups. During the hospitalization, in the group of patients with MINOCA there was a downward trend in β -ARM. In the control group, there was a tendency to increase of β -ARM. A statistically significant correlation of β -ARM with the ejection fraction (r=0,83, p=0,0007) and a moderate correlation between the p-ARM level on the 4 th day and GRACE risk (r=0,55, p=0,03) in patients of the control group were revealed. Conclusion.  β-ARM values in patients with MINOCA were doubled, and this increase was comparable to levels in patients with obstructive CAD. During the hospitalization, the β -ARM levels did not significantly change, despite the use of beta-blockers.