Discovery of Homobivalent Bitopic Ligands Of The Cannabinoid Cb2 Receptor
2020
Single chemical
entities with potential to simultaneously interact with two binding sites are
emerging strategies in medicinal chemistry. We have designed, synthesized and
functionally characterized the first bitopic ligands for the CB2 receptor.
These compounds selectively target CB2 versus CB1 receptors. Their binding mode
was studied by molecular dynamic simulations and site-directed mutagenesis
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI