Inspiratory-expiratory responses to alternate-breath oscillators of PACO2 and PAO2

Abstract Breath-by-breath respiratory responses of three healthy adults to imposed alternate-breath oscillation of end-tidal P CO 2 (between + 5 and + 15 torr above the 80 and 45 torr) were studied at rest and during mild cycle ergometer exercise. There was often alternation in inspiratory and expiratory tidal volumes and mean flows, and in expiratory duration, but not in inspiratory duration. The latency of responses, estimated by cross-correlation, corresponded closely to the lung-ear transport delay (measured by oximetry. There were two general patterns of response: in-phase , with inspiratory responses leading expiratory, and, more often, out-of-phase , with expiratory responses leading inspiratory. These patterns were associated with arrival of the onset of the alternating signal at the ear in inspiration and expiration, respectively. It is concluded that the timing of alternating humoral signals at the carotid bodies in relation to determines the pattern of inspiratory-expiratory response, and that expiratory events can be independent of the previous inspiration.