Механизмы и клиническое значение нефропротективного действия ингибиторов натрий-глюкозного котранспортёра 2 типа
2019
The issue of mechanisms and clinical significance of nephroprotective action of sodium-glucose cotransporter 2 (SGLT2) inhibitors is dealt with. Discussed are the manifestations related to the following effects of the members of this pharmacological group: their influence on glomerular filtration rate, glycaemia, diuresis, ketogenesis and other factors. The results of recent experimental and clinical studies revealing particular aspects of nephroprotective action of SGLT 2 inhibitors in type 2 diabetes mellitus and other pathological conditions are analyzed.
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