AB0935 Musculoskeletal Involvement in A Study of 50 Patients with Sarcoidosis

Background Sarcoidosis is a multisystem disease of unknown etiology. Patients with sarcoidosis may develop extrapulmonary organ involvement, including rheumatologic complications. Joint manifestations, including arthritis and periarthritis, occur in 14–38%. Objectives To analyze the pattern of osteoarticular lesions in patients with sarcoidosis hospitalized in internal medicine departments. Methods We carried out a systematic retrospective analysis of cases with sarcoidosis admitted in the last 38 years, using hospital databases. We assessed the following items: distribution of arthritis, chronicity, systemic manifestations, biochemical measures. Results We included 50 patients (75% women).Osteoarticular symptoms revealed the disease in 60% of patients. The mean age at the onset of symptoms of sarcoidosis was 42.47 years [18-70]. The average time between onset of symptoms and diagnosis was 17.74 months. Inflammatory polyarthritis was the most common symptom found in 28 patients (56%) mainly affecting the large joints, and were bilateral and symmetrical in all cases. Arthralgia hits both knees in 22 cases, elbows in 16 cases, wrists in 13 cases ankles in 11 cases, and shoulders in 4 cases. Polyarthritis were revealing in 9 cases (18%). They were asymmetric in 3 cases. Acute polyarthritis was noted in 5 cases (10%) and chronic in 4 others (8%).Plain radiographs were performed in 30 cases and no anomalies were found in all cases. Muscle involvement was noted in one case (2%). The diagnosis of sarcoidosis has been selected on clinical and laboratory, radiological and histological findings in all cases. Conclusions Rheumatic manifestations have been reported to occur in 4% to 38% of patients and may manifest clinically as inflammatory arthritis, periarticular soft tissue swelling, tenosynovitis, dactylitis, bone involvement, or myopathy. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5703