Mechanisms, Pathology And Therapeutic Interventions Of Restenosis

Restenosis is a particular problem in small vessels following a successful percutaneous transluminal coronary angioplasty remains the main obstacle to this technique for myocardial revascularisation. The occurrence of restenosis, which is now known to be caused by both vessel remodelling and neointimal hyperplasia, might be reduced in the future by a combined mechanical and pharmacological approach. Despite intensive investigation in this area, no pharmacological therapy has yet been found to be useful in preventing restenosis after conventional balloon angioplasty. Though dramatic improvements in catheter and stent technology, in stent restenosis continue to hamper initial procedural success in patients undergoing coronary intervention. With the advent of drug eluting stents, opportunities for even greater long term success appears to be a reality.