ESPIROCROMANONA SUBSTITUTED DERIVATIVES AS INHIBITORS acetyl CoA carboxylase

REFERRED TO ESPIROCROMANONA derivative of formula (I), wherein Ar1 is an aromatic ring such as indole, benzimidazole, 1,2-benzisoxazole, among others; R1 is phenyl, tetrazolyl, pyridyl, among others; R3 and R4 are H, halogen, nitro, C3-C6, among others. Preferred compounds: 1 - [(1-ethyl-4-methoxy-1H-benzimidazol-6-yl) carbonyl-6- (1H-tetrazol-5-YL) PIPERIDINE ESPIROCROMANO-2,4'-] -4-ONA , 1 '- [(1-cyclopropyl-4-methoxy-1H-indol-6-yl) carbonyl] -6- (5-Oxo-4,5-dihydro-1,2,4-oxadiazol-3-YL) SPIRO [chroman-2,4'-piperidine] -4-one, 3- {1 '- [(1-cyclopropyl-4-methoxy-1H-indol-6-yl) carbonyl] -4-oxospiro [chroman-2 , 4'-piperidine] -6-yl} SODIUM BENZOATE, among others. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION. Such compounds are inhibitors of acetyl CoA carboxylase (ACC) and are useful in the treatment of vascular diseases, nervous system, metabolic diseases, among others