Paliperidone and paliperidone derivative injectable sustained-release gel

The invention discloses a sustained release gel for injection for paliperidone and paliperidone derivative. The sustained release gel consists of paliperidone or paliperidone derivative, lactide-glycolide and dimethyl sulfoxide. The sustained release gel disclosed by the invention has small initial burst and high drug-loading rate and the dosages of a polymer and an organic solvent in the drug delivery system is reduced greatly; not only the production cost is reduced, but more significantly, the discomfort at the injection site is improved effectively; the sustained release formulation is more beneficial to improving compliance of a patient and provides a valuable option to the clinical care for metal diseases.