Clinial data analysis of 234 patients with intractable temporal lobe epilepsy

Objective To provide data for improving the treatment effect on intractable temporal lobe epilepsy by retrospectively analyzing the clinical data of a large number of patients.Methods Two hundred and thirty-five patients with intractable temporal lobe epilepsy,admitted to our hospital from January 2000 to December 2010,were chosen in our study; these patients had a follow up for over 6 months; their clinical data,including neural electrophysiology,imaging and histopathology,were retrospectively analyzed to compare the treatment efficacy of different types of patients at different time points of treatment.Results Neural electrophysiology showed unilateral epileptiform discharges in 167 patients,bilateral epileptiform discharges in 67 patients; further study showed that lateral dominance was noted in 38 and bilateral equalization in 29 patients of the 67 patients with bilateral epileptiform discharges.In the second year of operation,based on the Engel standard,patients with unilateral epileptiform discharges had significantly better effect than those with bilateral epileptiform discharges (P＜0.05).Imaging showed that hippocampal sclerosis had the highest percentage (41.5％,97/234),with highest postoperative satisfaction rate (Engel I was noted in 82 patients).Conclusion Patients with unilateral focal lesions and patients with hippocampal sclerosis have good surgical results. Key words: Temporal lobe epilepsy;  Surgical treatment;  Retrospective study