Natural Antioxidants and Colorectal Cancer: A New Approach

IntroductionColorectal cancer (CRC) is a multifactorial disease; genetic epigenetic and environmental factors as well as oxidative stress could be responsible for its onset and progression. Several studies have documented the importance of natural antioxidants in countering oxidative stress and thus preventing colorectal carcinogenesis. ObjectiveThis study aimed to test the protective effect of a mixture of antioxidants against CRC progression in a colorectal cancer mouse model at cellular, microscopic and macroscopic levels. MethodsMale C57BL/6 mice were divided into 4 groups, Group 1 given the mixture (M) which contains Curcumin, Resveratrol, Quercetin, EGCG and Cruciferex PB (0.1 mg/mL + DSS (1.5%) + AOM (10mg/kg)). Group 2, M (1 mg/mL + DSS (1.5%) + AOM (10mg/kg)). Group 3, M (1 mg/mL) and Group 4, (DSS (1.5%) + AOM (10mg/kg)). Body weight, intake of drinking water and diet were recorded every day. Two sacrifices were made (week 7 & 14) and biopsies of the liver, small intestine, colon and kidneys wer...