Regression of cytomegalovirus retinitis after decreased doses of immunosuppressive agents in a renal transplant recipient

A renal transplant recipient treated with immunosuppressive agents complained of blurred vision in 1 eye. Hemorrhages and fluffy, white retinal lesions were seen in both fundi. Cytomegalovirus (CMV) DNA was detected in the vitreous. Dosages of cyclosporine and methylprednisolone were decreased, and the azathioprine regimen was discontinued. No anti-CMV agents were given. The retinitis diminished markedly. Possibly, CMV retinitis in immunosuppressive conditions other than acquired immunodeficiency syndrome may regress if dosages of immunosuppressive drugs are decreased.