Dominant and recessive genetic models of LSP1 Gene rs3817198 Polymorphism and Breast Cancer Risk: A Systematic Review and Meta-analysis Study

Abstract: The aim of this meta-analysis is to predict effect of dominant and recessive genetic models of LSP1 gene rs3817198 polymorphism and breast cancer risk. We performed the meta-analysis according to PRISMA protocol. Three databases including PubMed/Medline, Web of sciences and EMBASE was searched. We included all studies that evaluated association of LSP1 gene rs3817198 and breast cancer risk in this meta-analysis. ORs and their reported 95% confidence interval (CI) for dominant and recessive inheritance models were extracted form final retrieved studies. ORs were pooled using both fixed and the random-effect models. Egger’s test and contour-enhanced funnel plot was used to evaluate Publication bias and small study effect. Twelve publications were eligible for final analysis after applying of inclusion and exclusion criteria. Totally, this meta-analysis composed of 15,530 cases and 20,258 controls. This study revealed significant association between LSP1 gene rs3817198 polymorphism and breast cancer in dominant genetic model (OR=1.07 [1.01-1.14]). Inversely, no association was found in recessive genetic model (OR=1.10 [0.93-1.32]). Subgroup analysis displayed a significant association in population-based studies and European & American & African population only in dominant genetic model. Begg’s funnel plot and Egger’s test were used for assessment of publication bias and confirmed no publication bias. Finally, we think LSP1 gene rs3817198 polymorphism is associated with breast cancer risk and the risk is more prominent in Caucasians. Nevertheless, further studies are required to confirm the association.