Clinical significance and changes of inflammatory cytokines in patients suffered from progressive cerebral infarction

Objective To observe and analyze the changes of inflammatory cytokines levels in patients with progressive cerebral infarction(PCI). Methods The patients with progressive cerebral infarction(progressive cerebral infarction group), the patients with non-progressive cerebral infarction(non progressive cerebral infarction group) and the healthy individuals(control group) were selected as the research subjects.Sixty individuals were included in each group.The levels of IL-8, hs-CRP, SAA of the research subjects were detected and observed. Results The levels of IL-8[(201.89±46.41)mg/L], hs-CRP[(16.55±4.49)mg/L], SAA[(20.65±4.17 )mg/L]of the progressive cerebral infarction group were significantly higher than those of non-progressive cerebral infarction group[(132.02±40.26 )mg/L, (8.09±4.06)mg/L and (15.35±4.07 )mg/L). ]The differences were statistically significant (t=4.289, P=0.000; t=2.276, P=0.006 and t=2.269, P=0.031). Compared with the control group[(50.70±31.14 )mg/L, (0.70±0.11 )mg/L and (5.15±2.21)mg/L], the levels of IL-8, hs-CRP, SAA in the progressive cerebral infarction group and non-progressive cerebral infarction group were significantly higher on the first day ( PCI group vs control: t=3.614, P=0.000; t=3.406, P=0.007; t=2.559, P=0.009; NPCI group vs control: t=3.602, P=0.000; t=3.181, P=0.009; t=1.520, P=0.026). Conclusion The changes of the inflammatory factors levels such as IL-8, hs-CRP, SAA have certain predicative value on the development of the PCI. Key words: Progressive cerebral infarction; Non progressive cerebral infarction; Inflammatory cytokines