SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice.

Hua-chuan Zheng,Takafumi Nakamura,Yang Zheng,Yuko Nakanishi,Yoshiaki Tabuchi,Akio Uchiyama,Hiroyuki Takahashi,Yasuo Takano

SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice.

2009

Hua-chuan Zheng
Takafumi Nakamura
Yang Zheng
Yuko Nakanishi
Yoshiaki Tabuchi
Akio Uchiyama
Hiroyuki Takahashi
Yasuo Takano

Purpose Simian Vacuolating Virus 40 (SV40) T antigen perturbed p53 and RB to cause cell malignant transformation. The purpose of this study was to identify the molecular changes during lens carcinogenesis and cancer progression induced by SV40 T antigen.

Keywords:

Cell cycle
Cell growth
Cytotoxic T cell
Malignant transformation
Immunology
Carcinogenesis
Simian Vacuolating Virus 40
Antigen
Apoptosis
Biology
Programmed cell death

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations