Retrospective view of the use of detoxifying hemosorption for the treatment of acute exogenous poisoning

Abstract Results of the treatment of almost 5000 patients with severe forms of acute poisoning by hemosorption (HS) using non-selective hemosorbents is a basic method comprising specific and non-specific therapeutic modalities that facilitate removal of toxicants of different nature from the human body. It is shown that natural biotransformation of toxicants and correction of disturbed hemostasis can be accelerated by a combination of HS and physico-chemical hemotherapy (magnetic, UV, and laser therapy, indirect electrochemical blood oxidation by sodium hypochlorite) that promotes further significant increase in the toxicant removal rate. Improvement of detoxification therapy by combining HS with other afferent methods for detoxification and physico-chemical hemotherapy allowed the mortality rate in the department of emergency antitoxic therapy to be reduced by a factor of 3, from 14.5 to 5.8%.