Photodynamic antimicrobial chemotherapy activity of (5,10,15,20-tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III).

Abstract (5,10,15,20-Tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III) (complex 1 ) was conjugated to platinum nanoparticles (PtNPs) (represented as 1 -PtNPs). The resulting conjugate showed 18 nm red shift in the Soret band when compared to 1 alone. Complex 1 and 1 -PtNPs showed promising photodynamic antimicrobial chemotherapy (PACT) activity against Staphylococcus aureus , Escherichia coli and Candida albicans in solution where the log reductions obtained were 4.92, 3.76, and 3.95, respectively for 1 -PtNPs. The singlet oxygen quantum yields obtained were higher at 0.56 for 1 -PtNPs in DMF while that of 1 was 0.52 in the same solvent. This resulted in improved PACT activity for 1 -PtNPs compared to 1 alone.