Novel perioperative parameters-based nomograms for survival outcomes in upper tract urothelial carcinoma after radical nephroureterectomy.

414Background: Recently, several postoperative nomograms for cancer-specific survival (CSS) after radical nephroureterectomy (RNU) were proposed, while they did not incorporate the same variables; meanwhile, many preoperative blood-based parameters, which were recently reported to be related to survival, were not included in their models. In addition, no nomogram for overall survival (OS) was available to date. Methods: The full data of 716 patients were available. The whole cohort was randomly divided into two cohorts: the training cohort for developing the nomograms (n = 508) and the validation cohort for validating the models (n = 208). Univariate and multivariate Cox proportional hazards regression models were used for establishing the prediction models. The discriminative accuracy of nomograms were measured by Harrell’s concordance index (C-index). The clinical usefulness and net benefit of the predictive models were estimated and visualized by using Decision curve analyses (DCA). Results: The median...