Морфофункциональные основы развития сосудистых когнитивных и эмоциональных расстройств

Objective: to investigate cerebrovascular reactivity (CVR) and brain matter structural changes in patients with moderate cognitive impairment. Patients and methods. A total of 385 patients aged 57 to 79 years with moderate vascular cognitive impairment (VCI) were examined. A rela￾tionship of the clinical types of VCI and depression to the extent and location of ischemic brain matter damage and to the state of CVR in different vascular beds was investigated at the stage of inclusion into the study and following 20 months. Results. There was a correlation of the neuropsychological profile and the severity of VCI with the features of brain matter structural damage, but with a greater CVR decrease in the carotid artery (CA) system and a concomitant CVR reduction in the CA and vertebrobasilar bed (VBB). There was an association of the incidence of depression with the location of ischemic damage in the frontal lobes and a CVR decrease in the left CA and with a concomitant CVR reduction in the CA and VBB. Conclusion. The CVR determined in different vascular beds may serve as an early prognostic indicator of evolving VCI or depression.