DNA visualization and exploration of 3D genomic structures

The use of rejects outlets in vortex separators having internal walls which gradually transform from a circular cross-section into openings which are noncircular in cross-section has been found to be effective in controlling the rejects rate and the thickening factor of the separators while maintaining effective cleaning efficiencies without plugging problems. The rejects outlets may be fabricated as replaceable tips or may be integrally formed with the cyclone bodies.