ASYMPTOMATIC RENAL DISEASE IN DIABETIC AND NON-DIABETIC HYPERTENSIVE PATIENTS

INTRODUCTION: In hypertensive patients, especially those with diabetes, renal disease is frequently asymptomatic. Early diagnosis of nephropathy has importance in terms of establishing the appropriate therapy. THE AIM of the study was to compare the methods used for the diagnosis of asymptomatic nephropathy: the traditional method based on creatinine dosage and the modern cystatin C measurement, combined with the application of formulas used in hypertensive patients in the presence and absence of diabetes. MATERIAL AND METHODS: The study was carried out on patients from the Procardia medical unit in Tirgu Mures, we processed the data obtained during October 2013 - February 2014, and April - June 2015. 150 patients with stage II and III hypertension were included in the study. Serum lipids, blood glucose, creatinine, urea and in selected cases cystatin C levels were determined, and body mass index was calculated. Glomerular filtration rate was determined using the MDRD (Modification of Diet in Renal Disease) and EGFR. (Cock-Croft) calculation formulas. Statistical analysis of the data was performed using Excel and GraphPad InStat programs. RESULTS: In the studied patient groups stage II hypertension (71%) was predominant, diabetes was associated with hypertension in 21% of the cases. Negative correlation was obtained between serum creatinine and the MDRD creatinine or creatinine eGFR, and positive correlation between MDRD-creatinine and eGFR-creatinine, and also between MDRD-creatinine and MDRD-cystatin C (p The distribution of body mass index showed the highest percentage of overweight and grade I obese patients. CONCLUSIONS: Most patients present some kidney disorder, for the diagnosis of renal diseases formulas for evaluation of glomerular filtration are very helpful. Cystatin C is a reliable marker of renal function, showing early nephropathy, therefore it would be useful to enter the diagnostic arsenal in justified cases. Keywords: arterial hypertension, diabetes mellitus, nephropathy, MDRD, cystatin C Normal 0 21 false false false RO X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-fareast-language:EN-US;}