Electro-organic synthesis of 1-(3-chloro-2-hydroxy propyl)-2-methyl-5-aminoimidazole in acidic medium

Electro-organic synthesis of 1-(3-chloro-2-hydroxy propyl)-2-methyl-5-aminoimidazole has been carried out by the constant current electrolysis at copper and amalgamated forms of copper and lead electrodes under acidic conditions. The electro reduction of 1-(3-chloro-2-hydroxy propyl)-2-methyl-5-nitroimidazole (Ornidazole) has been also studied by cyclic voltammetry at glassy carbon electrode under acidic conditions which indicate the reducible behaviour of it. Isolated product was characterized by TLC, usual laboratory qualitative tests and IR, NMR spectral analysis. Effect of different parameters like current density, temperature, depolarizer concentration and nature of cathode material on yield percentage and current efficiency have been investigated. Number of electrons have also been calculated to confirm the isolated product, which is 1-(3-chloro-2-hydroxy propyl)-2-inethyl-5-nitroimidazole.