REVIEW ARTICLE Kikuchi-Fujimoto disease: an unusual association with acute renal failure

ABSTRACT Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis of unknown etio-pathogenesis, is a self-limited disease which frequently appears as feverish lymphadenomegaly, thus creating the need for differential diagnosis with lymphoma, systemic lupus erythematosus (SLE), infectious mononucleosis, cat-scratch disease, and toxoplasmosis with lymphonodal impairment. However, there are cases in which it may evolve with complications such as aseptic meningitis, cer-ebellar ataxia, and aseptic myocarditis. We are presenting a case of a 24-year-old man who had an initial picture of arthralgia, evening fever and adenomegaly. Kikuchi disease was diagnosed through lymph node biopsy with immunohistochemistry and evolves with severe systemic manifestations, such as pericarditis with cardiac tamponade, pneumonitis, hepatitis, and acute kidney failure - the latter has not been reported in literature yet. There was signifi cant improvement of the clinical picture with prednisone.Keywords: Kikuchi-Fujimoto disease; histiocytic necrotizing lymphadenitis; acute renal failure.