FREQUENCY AND ANTIBIOTIC RESISTANCE IN CLINICAL ISOLATES ACINETOBACTER BAUMANNII

Multidrug resistant Gram-negative bacteria represent a global problem due to their global spread and growing distribution. They lead to major difficulties in therapy and to increased lethality and much more expensive treatment. Acinetobacter baumannii is a typical agent of this group of microorganisms. The purpose of this study is to determine the frequency of distribution of A. baumannii in a variety of clinical materials of hospital patients and their antibiotic resistance to different groups of antibiotics used in medical practice. Methods: A total of 371 strains A. baumannii were tested. They were isolated from clinical materials of patients of “St. Kirkovich Hospital"Medical University, Stara Zagora for a five-year period (2010-2014). The identification of the isolates was done by: routine methods, semi-automated Crystal system and automated API system. The disc diffusion method of Bauer Kirby was used to determine the antibiotic resistance. Results: Among the 371 isolated strains of A. baumannii dominate those of surgical wounds /40.2%/, followed by isolates of the respiratory system (27.2%). Antibiotic resistance to different antibiotic classes shows: Piperacillin - 92.3% R, Ampicillin / Sulbactam - 69% R, Ceftazidime - 91.6% R, Cefepime - 91% R, Imipenem - 32.7% R, Meropenem - 48.9% R, Amikacin - 76.2% R, Ciprofloxacin -86.6% R.