Derivatives of piridinil and pyrimidil substituted as modulators of metabolism and the treatment of disorders related to the same.

Compound selected from the compounds of Formula (Ia) and pharmaceutically acceptable salts, solvates and hydrates thereof: Wherein, X is N or CR8 wherein R8 is H or a halogen; Y is NH or O: Z is CH or N; R1 is carbo-C1-6 alkoxy, oxadiazolyl or pyrimidinyl, wherein said carbo-C1-6 alkoxy, oxadiazolyl and pyrimidinyl are optionally substituted with 1 or 2 substituents independently selected from: C1-4 alkyl, C1-4 alkoxy and C3-5 cycloalkyl; R2 is H or C1-4 alkyl; R3 is C1-4 alkoxy, O-C2-4-alkynyl, or hydroxyl; R4 is selected from: H, C1-4 alkoxy, C1-4 alkyl, C2-4 alkynyl and a halogen; R5 is selected from: C1-4 acylsulfonamide, C1-4 alkoxy, C1-4 alkyl, C1-4 alkylamino, C1-4 alkylsulfonyl, C1-4alkylthio, cyano group, heterocyclyl, di-C1-4, -dialkylamino and sulfonamide, wherein said C1-4alkoxy, C1-4alkyl, C1-4alkylamide, C1-4alkylaminium, C1-4alkylsulfonyl, C1-4alkylthio, C1-4-dialkylamino and heterocyclyl correspond to each of the optionally substituted with 1 or 2 substituents independently selected from: C2-4 alkynyl, C1-4alkoxy, C1-4alkylcarboxamide, C1-4 alqulsulfonyl, C3-5 cycloalkyl, C3-5 cycloalyloxy, diC1-4-alkylcarboxamide, hydroxyl and phosphonoxy, wherein said C1 -4 alkylcarboxamide is optionally substituted by hydroxyl; Or R5 is a group of Formula (A): Where; "m", "n" and "q" are each independently 0, 1, 2 or 3; "r" is 0, 1, or 2; and "t" is 0 or 1; R6 is H or a halogen; and R7 is H or C1-4 alkyl,