Genç Bireylerde Aspirin Ve Vitamin C Emiliminin Etkileşimi

The Interaction of Aspirin and Ascorbic Acid Absorption in Healthy Young Individuals Aspirin (acetylsalicyclic acid) and vitamin C (ascorbic acid) are commonly used two drugs. Metabolic importance of vitamin C has been risen due to understanding the function of vitamin C on metabolic pathway in human. To known how maintain serum and tissue levels in normal ranges is very crucial to avoid vitamin C deficiency. Therefore vitamin C and drug interaction, particulary for long term use, is very important to keep vitamin C in physiologic level. There have been some studies regarding the interaction of vitamin C and aspirin interaction indicating the inhibition of vitamin C absorption by aspirin. The present study, here, also reports inhibition of aspirin absorption by vitamin C. Aspirin ve vitamin C dunyada en cok tuketilen ilaclarin basinda gelmektedir. Vitamin C'nin insan organizmasmdaki metabolik fonksiyonlarinin aydinlatilmasi vitamin C'ye giderek daha fazla onem kazandirmistir. Uzun sureli aspirin kullanimini gerektiren hastaliklarda, aspirin ve vitamin C iliskisi ozel onem arz etmektedir. Daha once yapilan calismalarda vitamin C emiliminin, serum ve doku duzeylerinin aspirin tarafindan bozuldugu gosterilmistir. Vitamin C'nin aspirin emilimine nasil etkide bulunduguna dair bilgiye ise rastlanilmamistir. Bu calismamizda sigara icme aliskanligi olmayan, 22-24 yas arasi, toplam 39 saglikli bireyler arasinda vitamin C ve aspirin emiliminde karsilikli etkilesimin oldugu gosterilerek, serum aspirin duzeyinin vitamin C tarafindan etkilenebilecegi kanaatine varildi.