Is ultraviolette radiation avoidance affecting bone health in melanoma patients

Background Ultraviolet (UV) radiation has numerous beneficial effects on human health, including stimulating vitamin D and serotonin production and immuno-regulatory activities. Conversely, UV radiation is also classified as a group one carcinogen by the International Agency for Research on Cancer. Purpose To investigated the effects of UV radiation avoidance in melanoma patients in terms of vitamin D levels but also of bone mineral density and trabecular bone microarchitecture. Methods We conducted an observational study investigating the effects of UV radiation avoidance in 31 melanoma patients in terms of vitamin D levels but also of bone mineral density and trabecular bone microarchitecture by using dual-energy X-ray absorptiometry scan. Data were compared with two control groups of healthy subjects, who were chronically exposed or not exposed to UV radiation during their lifetime. Results Melanoma patients had on average slightly lower levels of vitamin D, without reaching statistical significance (p = 0.135). No significant difference was found across the three groups on T-scores of femoral neck (p = 0.544), of total hip (p = 0.617) and of lumbar spine p = 0.155). No significant difference was found on and trabecular bone score across exposure groups (p = 0.895). Conclusion UV radiation avoidance doesn't seem to significantly impact vitamin D levels nor bone health in melanoma patients. Thus, UV protective behavior is advisable for all melanoma patients.