to level or not histological examination of sentinel lymph nodes in patients with breast carcinoma
2020
Abstract Management of the axilla in patients with breast carcinoma has changed rapidly in recent years due to development of an increasingly
conservative approach to axillary staging. Sentinel node examination plays a pivotal role in subsequent decision for axillary lymph node
dissection. There is still no consensus on how best to examine SLNs histologically. The examination of sentinel node should be thorough
enough whilst not missing clinically significant information. The main goal of sentinel lymph node examination is to detect all
macrometastasis. In this study we have reviewed an extensive histological protocol to identify whether it resulted in detection of
clinically significant metastatic deposits. Our study identified that one hematoxylineosin–stained section along with immunostaining
for pancytokeratin from each block results in the detection of clinically significant metastases and hence recommended as the preferred
method of pathologic evaluation. Keywords Axillary node examination; Breast carcinoma; Sentinel node Abbreviations ALND: Axillary Lymph Node Dissection; MiM: Micrometastasis; SLN: Sentinel Lymph Node
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