Drug-induced modifications of the immune response 8. N-(Substituted phenyl)-2,5-dihydro-2-oxo-4-[(substituted phenyl) amino]-3-furancarboxamide derivatives

Abstract The synthesis and anti-allergic activity of a series of novel N -(substituted phenyl)-2,5-dihydro-2-oxo-4-[(substituted phenyl)amino]-3-furancarboxamide derivatives ( 12 ) are described. The latter were obtained through a novel, and heretofore unknown rearrangement of 2-( N -phenylamino)-4,5-dihydro-4-oxo-3-furancarboxylic acids 8a to the 2(5H)-furanone amides 12 .