Efficient, Protecting Group Free Kilogram-Scale Synthesis of the JAK1 Inhibitor GDC-4379

Andreas Stumpf,Johannes Burkhard,Di Xu,Andreas Marx,David Lao,Miriam Ochsenbein,Rohit Ranjan,Remy Angelaud,Francis Gosselin

Efficient, Protecting Group Free Kilogram-Scale Synthesis of the JAK1 Inhibitor GDC-4379

2021

Andreas Stumpf
Johannes Burkhard
Di Xu
Andreas Marx
David Lao
Miriam Ochsenbein
Rohit Ranjan
Remy Angelaud
Francis Gosselin

The development of an improved kilogram-scale synthesis of the JAK1 inhibitor GDC-4379 for the treatment of asthma is described. The new process is highlighted by a step-economical construction of ...

Keywords:

Chemistry
scale
Waste management
Kilogram
Protecting group

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