solid oral pharmaceutical preparation of aripiprazole and processes for their preparation
2002
A solid oral pharmaceutical preparation of aripiprazole having a) at least one dissolution rate measured after storage in the open at 25 ° C / 60% RH for six months selected from the group consisting 70% or more at pH 4, 5 after 60 minutes, and 55% or more at pH 5.0 after 60 minutes; b) at least one dissolution rate measured after storage in the open at 40 ° C / 75% RH for 1 week selected from the group consisting 70% or more at pH 4.5 after 60 minutes, and 55% or more at pH 5.0 after 60 minutes which is obtainable by wet granulating conventional Aripiprazole Crystals or Anhydrous Crystals conventional Aripiprazole Hydrate, drying the obtained granules at 70 to 100 ° C, sizing of thereof, optionally shaping them into tablets, and then drying the sized granules or tablets 70 to 100 ° C again.
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