Biosynthesis of asukamycin. Formation of the 2-amino-3-hydroxycyclopent-2-enone moiety

Akira Nakagawa,Tzay-Shiang Wu,Paul J. Keller,Jonathan P. Lee,Satoshi Ōmura,Heinz G. Floss

Biosynthesis of asukamycin. Formation of the 2-amino-3-hydroxycyclopent-2-enone moiety

1985

Akira Nakagawa
Tzay-Shiang Wu
Paul J. Keller
Jonathan P. Lee
Satoshi Ōmura
Heinz G. Floss

Feeding experiments with labelled precursors suggest that the 2-amino-3-hydroxycyclopent-2-enone moiety of the anticoccidial antibiotic, asukamycin, is formed by a novel intramolecular cyclization of 5-aminolevulinic acid.

Keywords:

Biosynthesis
Asukamycin
Chemistry
Moiety
Intramolecular force
Enone
Organic chemistry
Stereochemistry
intramolecular cyclization

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