Total synthesis of amphidinolactone A

Abstract A convergent total synthesis of amphidinolactone A has been achieved, the longest linear sequence being 17 steps with 15.2% overall yield, using a ring-closing metathesis reaction as the macrolactonization step. The RCM precursor was obtained by the union of acid and alcohol fragments derived from ( R )-epichlorohydrin and propane-1,3-diol, respectively. The side chain was incorporated following a Wittig reaction to exclusively obtain the cis -isomer.