Effect of qualitatively varying nutrition on several parameters of aflatoxin B1 metabolism and toxicokinetics

The influence of qualitatively different nutrition (physiological and that with lysine, methionine, threonine and vitamins A, B, C deficiencies) on certain toxicokinetic parameters of 3H-aflatoxin B1, after single and multiple (every day, during 5 days) intraperitoneal injections of this agent in a dose of 25 micrograms/animal, was studied in two series of experiments on growing male WAG rats with the initial bw 40-50 g. It has been proved that the main parameters of aflatoxin B1 toxicokinetics depend on the injection multiplicity and the nutrition character. It has been established that the qualitative differences in the nutrition character essentially influence the stages of aflatoxin B1 distribution in the body, the sorption and metabolic transformation in the liver, enterohepatic recirculation, the rate and correlation of the main elimination routes. The nutrition character influences the level of persistence and cumulation of firmly bound aflatoxin B1 adducts in the liver and hepatocytic DNA. Possible mechanisms of such effects of different providing of the body with essential nutrients have been discussed. A conclusion has been made that the modifying effect of nutrition on the key stages of aflatoxin B1 toxicokinetics is realized, ultimately, in varying degree of the animal resistance to mutagenic and carcinogenic action of this agent.