An Intronic RegionwithintheHuman FactorVilGene IsDuplicated within Xq28andIsHomologous tothe Polymorphic LocusDXSI15(767)

Summary Thegenomic sequencesrecognized bythe anonymous probe 767(DXS115) arelocalized totwosites within Xq28.Onesite lies within intron 22ofthefactor VIII gene(FBC). Physical mapping suggests that thesecond site lies within 1.2megabases oftheF8Cgene.TheRFLPsdetected by767arelocated within thesecond site. Genetic data suggestthat F8CandDXS115 aretightly linked (Omax = .04; Zma. = 8.30). Recombination eventsinmeioses informative forDXS52(Stl4), DXS115, andF8Csuggestthat DXS115 andF8Clie distal toDXS52.