Correlation between single nucleotide polymorphisms of IL-8 and susceptibility to cervical cancer.

Objective To investigate the relationship between single nucleotide polymorphisms of IL-8-251 A/T and the occurrence of cervical cancer.Methods A retrospective case-control study design Was applied for the present study.The cage group included peripheral blood samples from 217 cervical cancer patients and peripheral blood samples from 190 healthy women.Tetra-primer amplification refractory mutation system polymerase chain reaction Was used to analyze the genotype distribution and allele frequency of IL-8-251 A/T.Results It-8-251 MT gene polymowhisms included three genotypes:AA,AT and TT.Proportions of genotypes were 18.89%,53.46%,27.65%in cage group,respectively and were 35.79%,44.21%,20.00%in control group,respectively.There was statistical significance(P<0.05)between the case group and the control group.The risk of genotype TT and T allele for cervical cancer Wag 2.619 and 1.639.respectively.Conclusion IL-8-25 1 A/T may be a genetic susceptibility factors for cervical cancer. Key words: Cervical neoplasms; Interleukin-8; Polymorphism,single nucleotide