4DNvestigator: a toolbox for the analysis of time series Hi-C and RNA-seq data

The combined analysis of genome structure and function over time, and how these changes affect cellular phenotype, is referred to as the 4D Nucleome (4DN). 4DN analysis is necessary to fully understand how a cell operates, but 4DN analysis tools are currently underdeveloped. We present the “4DNvestigator”, a user-friendly toolbox for the analysis of time-series genome structure, measured by genome-wide chromosome conformation capture (Hi-C), and genome function, measured by RNA sequencing (RNA-seq).