Biochemical and morphological alterations caused by silver nanoparticles in Wistar rats

Abstract Objective This study evaluated the biochemical effect of the oral administration of silver nanoparticles on some biochemical parameters and tissue morphology. Methods Wistar rats of both sexes with an average weight of 160 ± 5 g were randomly assigned into four groups. Animals in Group 1 served as the control and received 0.5 mL of distilled water (drug vehicle). Those in Groups 2, 3, and 4 were administered with 10, 50, and 100 mg/kg body weight silver nanoparticles, respectively. The animals were sacrificed under slight anesthesia 24 hours after the last treatment. Results Silver nanoparticle exposure in rats elevated the level of rat serum total cholesterol, triacylglyceride, free glycerol, low density lipoprotein-cholesterol, and bilirubin ( p Conclusion We show evidence that silver nanoparticle potentiated biochemical changes predisposing to liver injury and cardiovascular disorder in rat.