Z-(±)-1-azabicyclo[2.2.1]heptan-3-one, O-(3-aryl-2-propynyl) oximes as potential m1-subtype selective muscarinic agonists

Abstract The synthesis and SAR of a series of Z-(±)-1-azabicyclo[2.2.1]heptan-3-one, O-(3-aryl-2-propynyl) oximes are described. The biochemistry and pharmacology of PD 142505 (5b), an oxime with pronounced functional ml selectivity, are highlighted.