The research progress of CC chemokines and Plasmodium infections

Malaria is a severe risk of disease that people are facing at present.The process of Plasmodium infection causes the change in the level of many chemokines which can recruit inflammatory cells infiltration, leading to the clearance of the parasites.As to the severe malaria, such as cerebral malaria and placental malaria, recruited inflammatory cells can also aggravate pathological reaction.CC chemokines, one subfamily of chemokines, are expressed during the process of Plasmodium infection, and are involved in the inflammatory process caused by Plasmodium invasion, they are very important to research and against the Plasmodium infection.This article reviews the biological effects of CCL2, CCL3, CCL5, CCL7, CCL11, CCL20 and CCL21, and provides the research progress on the relationship between the Plasmodium infection and the CC chemokines. Key words: Chemokines; CC subfamily; Plasmodium infection; Cerebral malaria; Placental malaria