Circulating microRNA plasma profile in MuSK+ myasthenia gravis

Abstract Muscle-specific tyrosine kinase antibody positive myasthenia gravis (MuSK+ MG) is an immunological subtype with distinctive pathogenic mechanisms and clinical features. The aim of this study was to analyze the circulating plasma microRNA profile of patients with MuSK+ MG. From the discovery cohort miR-210-3p, miR-324-3p and miR-328-3p were further analyzed in the validation cohort. We found a distinct plasma profile of miR-210-3p and miR-324-3p that were significantly decreased in MuSK+ MG patients compared to healthy controls (4.1 ± 1.4 vs 5.1 ± 1.4, p  = .006 and 4.7 ± 1.0 vs 5.4 ± 1.3, p  = .02). These findings reveal a distinct plasma miRNA profile in MuSK+ MG.