Plague; treatment of experimental animals with streptomycin, sulfadiazine, and sulfapyrazine.

Abstract 1.1. Three hundred and thirty-four white mice were inoculated with plague, and one-half were treated in groups with different amounts and varying dosage of either streptomycin, sulfadiazine, or sulfapyrazine. The other one-half were used as controls. Under the treatment schedules finally adopted, from sixteen to eighteen survived among each lot of from eighteen to twenty, while all the corresponding controls died with plague. 2.2. Forty-eight guinea pigs were likewise inoculated, and one-half were treated with streptomycin in two groups after clinical evidence of infection had developed. All survived, but eight had residual buboes at necropsy. Twenty-three controls died with plague. 3.3. One hundred six guinea pigs were infected through flea transmission. After the disease was evident clinically, fifteen were treated with streptomycin and fourteen survived; fifteen received sulfadiazine and fourteen survived; ten received both these drugs and all survived; sixteen received sulfapyrazine and ten survived. Six among all the survivors had residual buboes at necropsy. Three survived among fifty controls divided among the four lots treated. 4.4. Clinical recurrences appeared frequently under the treatment schedules used with streptomycin and sulfapyrazine but not with that of sulfadiazine.