PISARRO: A EUTROC phase Ib study of APR-246 in combination with carboplatin (C) and pegylated liposomal doxorubicin (PLD) in platinum sensitive relapsed high grade serous ovarian cancer (HGSOC).

Charlie Gourley,John Green,Hani Gabra,Ignace Vergote,Bristi Basu,James D. Brenton,Ulf Björklund,Austin M. Smith,Mikael Von Euler

PISARRO: A EUTROC phase Ib study of APR-246 in combination with carboplatin (C) and pegylated liposomal doxorubicin (PLD) in platinum sensitive relapsed high grade serous ovarian cancer (HGSOC).

2016

Charlie Gourley
John Green
Hani Gabra
Ignace Vergote
Bristi Basu
James D. Brenton
Ulf Björklund
Austin M. Smith
Mikael Von Euler

5571Background: P53 is ubiquitously mutated in HGSOC. APR-246 is a novel agent which stabilises mutant P53 in the wild-type conformation, increasing cancer cell chemo-sensitivity. Our aim was to es...

Keywords:

Pegylated Liposomal Doxorubicin
Ovarian cancer
Carboplatin
Cancer research
Pathology
Platinum
Serous fluid
Medicine
Cancer cell
serous ovarian cancer
platinum sensitive

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